Med J Aust; 193(9):525-32. https://www.uptodate.com/ (Requires subscription). Monitor Closely (1)ibuprofen/famotidine will decrease the level or effect of iron sucrose by increasing gastric pH. Then enter the value of the Dosage and choose the unit of measurement from the drop-down menu. Normal haemoglobin values are gender specific: for males from 13.8 to 18.0 g/dL (138 to 180 g/L, or 8.56 to 11.17mmol/L) and females from 12.1 to 15.1 g/dL (121 to 151 g/L, or 7.51 to 9.37mmol/L). Intravenous (IV) iron products (use in adults) Dosing information in this table is for adults and includes some dosing recommendations not listed in the approved product information. You may need extra iron because of blood loss during kidney dialysis. Generic name: IRON SUCROSE 20mg in 1mL Excessive therapy with parenteral iron can lead to excess storage of iron with the possibility of iatrogenic hemosiderosis. . Venofer (iron sucrose) dose calculator | Calculosaurus.com concentration of elemental iron (mg/ml) in the product being used: This calculator will help pinpoint potential causes of anemia based on an automated flowchart approach. 1998 Feb;25(1):65-8. Modify Therapy/Monitor Closely. David McAuley, Pharm.D. Modify Therapy/Monitor Closely. Applies only to oral form of both agents. FERAHEME Dosing & Administration - Feraheme FERAHEME has flexible dosing for your patients FERAHEME flexible scheduling gives your patients the freedom to receive the iron they need as early as 3 days apart 1 FLEXIBLE DILUTION OPTIONS 1 Dilute full contents of vial (17 mL) in 50 mL to 200 mL of: 0.9% NaCl, or 5% dextrose STORAGE 1 Applies only to oral form of both agents. We'll do this entirely for free, as long as the calculator has applications for women's health. Administer on 5 different occasions over a 14 day period. Assessing new treatment options, Intravenous iron-dextran: therapeutic and experimental possibilities. Venofer (iron sucrose injection, USP) is a brown, sterile, aqueous, complex of polynuclear iron (III)- . Symptoms associated with Venofer total dosage or infusing too rapidly included hypotension, dyspnea, headache, vomiting, nausea, dizziness, joint aches, paresthesia, abdominal and muscle pain, edema and cardiovascular collapse. provider for the most current information. Use Caution/Monitor. 1990 Feb;24(2):162-6. Administer a test INFeD dose prior to the first therapeutic dose. The dosing for iron replacement treatment in pediatric patients with Peritoneal or Hemodialysis-Dependent - CKD or Non-Dialysis Dependent CKD have not been established. Immune system disorders: Anaphylactic-type reactions, angioedema, Nervous system disorders: Convulsions, collapse, light-headedness, loss-of-consciousness, Respiratory, thoracic and mediastinal disorders: Bronchospasm, dyspnea, Musculoskeletal and connective tissue disorders: Back pain, swelling of the joints, General disorders and administration site conditions: Hyperhidrosis, Published studies on intravenous iron sucrose treatment after first trimester of pregnancy not shown adverse maternal or fetal outcomes; available reports of intravenous iron sucrose use in pregnant women during first trimester are insufficient to assess risk of major birth defects and miscarriage; iron deficiency anemia during pregnancy should be treated because there are risks to mother and fetus associated with untreated iron deficiency anemia (IDA) in pregnancy; risks to fetus associated with maternal severe hypersensitivity reactions, Severe adverse reactions including circulatory failure (severe hypotension, shock including in the context of anaphylactic reaction) may occur in pregnant women with parenteral iron products which may cause fetal bradycardia, especially during second and third trimester, Iron sucrose is present in human milk, and available published reports following exposure to 100-300 mg intravenous iron sucrose have not reported adverse reactions in breastfed infants; there are no data on effects on milk production, Developmental and health benefits of breastfeeding should be considered, along with mothers clinical need for treatment and any potential adverse effects on breastfed child from therapy or from underlying maternal condition. Deferasirox chelates iron. Iron stores 500 mg for body weight greater than or equal to 35 kg (77 lbs) and 15 mg/kg for body weight less than 35 kg. Symptoms of a serious allergic reaction may include: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.This is not a complete list of possible side effects. Monitor Closely (1)iron sucrose decreases levels of liothyronine by inhibition of GI absorption. Hemoglobin iron deficit = 60 x (14 - 8) x (2.145) = 772 mg iron. Read our. The above information is provided for general Equations used: 1] Calculation of the Total Iron Deficit: Total iron deficit [mg] = body weight [kg] x (target Hb-actual Hb) [g/dl] x 2.4 + depot iron [mg]. 1000 mg. 20 MINUTES. iron sucrose decreases levels of tetracycline by inhibition of GI absorption. Avoid or Use Alternate Drug. Patients may present with shock, clinically significant hypotension, loss of consciousness and/or collapse. Other indications for IV are pregnancy iron deficiency, chronic renal impairment or need for rapid repletion. Information last revised December 2022. Situation Analysis Market Size MAT Sales Cr LC MAT Share % MAT Gr % Total Pharma Market 9388.69 100 13.5 Iron Sucrose 11.18 93.81 37.65 Brand Company Saline MAT . 1. 2022 American Regent, Inc.PP-VE-US-0016 (v6.0)1/2022. Then you can click on the Print button to open a PDF in a separate window with the inputs and results. Administer Venofer early during the dialysis session (generally within the first hour). Minor/Significance Unknown. Ganzoni AM. Use Caution/Monitor. Venofer is given as an infusion into a vein. Step 2: Calculation and administration of the maximum individual iron dose(s): . No additional iron to replenish stores. Applies only to oral form of both agents. Hemoglobin there are two fields for hemoglobin input, one for the target and another for actual value. an automated flowchart approach. 0.5 mg/kg (not to exceed 100 mg/dose) diluted to a concentration of 1 to 2 mg/mL in 0.9% sodium chloride IV over 5 to 60 minutes Administer every 4 weeks for 12 weeks Do not dilute to concentrations below 1 mg/mL Comments: Treatment may be repeated if necessary. Applies only to oral form of both agents. There is limited experience with administration of an infusion of 500 mg of Venofer, diluted in a maximum of 250 mL of 0.9% NaCl, over a period of 3.5 to 4 hours on Day 1 and Day 14. Hypotension following administration of Venofer may be related to rate of administration and/or total dose delivered. Intravenous iron sucrose: establishing a safe dose. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9yZWZlcmVuY2UubWVkc2NhcGUuY29tL2RydWcvdmVub2Zlci1pcm9uLXN1Y3Jvc2UtMzQyMTYy, View explanations for tiers and Separate dosing of tetracyclines from these products. Monitor Closely (1)didanosine will decrease the level or effect of iron sucrose by increasing gastric pH. SIDE EFFECTS: Muscle cramps, nausea, vomiting, strange taste in the mouth, diarrhea, constipation, headache, cough, back pain, joint pain, dizziness, or swelling of the arms/legs may occur. Use Caution/Monitor. Serious - Use Alternative (1)iron sucrose decreases levels of gemifloxacin by inhibition of GI absorption. Calcs that help predict probability of a disease, Subcategory of 'Diagnosis' designed to be very sensitive, Disease is diagnosed: prognosticate to guide treatment. sodium sulfate/potassium sulfate/magnesium sulfate decreases levels of iron sucrose by inhibition of GI absorption. Serious - Use Alternative (1)iron sucrose decreases levels of tetracycline by inhibition of GI absorption. Use Caution/Monitor.Minor (2)calcium carbonate decreases levels of iron sucrose by inhibition of GI absorption. Calculation of Dosage of Nefrofer Total Iron Deficit (mg) Nefrofer (ml) = 20mg/ml Total Iron Deficit (mg) = Body weight (kg) x (Target Hb - Actual Hb) [g/l] x 0.24* + Depot Iron . Administer iron products at least 2 hr before and no less than 6 hr after each dose to avoid chelation with magnesium. Case G. Maintaining iron balance with total-dose infusion of intravenous iron dextran. The usual total treatment course of Venofer is 1000 mg. Venofer treatment may be repeated if iron deficiency reoccurs. Manage and view all your plans together even plans in different states. Deferiprone may bind polyvalent cations (eg, iron, aluminum, and zinc), separate administration by at least 4 hr between deferiprone and other medications (eg, antacids), or supplements containing these polyvalent cations. This drug is available at a higher level co-pay. Applies only to oral form of both agents. Administer Venofer early during the dialysis session (generally within the first hour). Venofer treatment may be repeated if iron deficiency reoccurs. Assure stable intravenous access to avoid extravasation. sodium bicarbonate will decrease the level or effect of iron sucrose by increasing gastric pH. Slow or stop the infusion if adverse reactions occur. Venofer (Iron Sucrose Injection) may treat, side effects, dosage, drug interactions, warnings, patient labeling, reviews, and related medications including drug comparison and health resources. 1 ,*. Dosing for patients who weigh 50 kg or more For patients weighing 50 kg (110 lb) or more: Give Injectafer in two doses separated by at least 7 days. This health tool computes the required parenteral iron replacement dose for the iron deficit extracted from the patient weight and hemoglobin level from complete blood count test. Treatment of iron deficiency anemia in adults - UpToDate iron sucrose will decrease the level or effect of baloxavir marboxil by cation binding in GI tract. Use Caution/Monitor. Avoid or Use Alternate Drug. Controlled studies in pregnant women show no evidence of fetal risk. 1) Ganzoni AM. Iron deficiency anemia calculator (diagnosis), Iron deficiency anemia vs. Applies only to oral form of both agents. These adverse reactions have occurred up to 30 minutes after the administration of Venofer injection. The following table present normal hemoglobin ranges: There is another equation for iron deficit that can be used to calculate replenishment needs, that of Ganzoni, which takes into account iron stores as well and that can be found in the iron deficit calculator. ------------------------------------------------------------------------- Iron Dextran Complex [ Infed ] Elemental iron: 50 mg of elemental iron per mL [2 mL] [package insert] BOXED WARNING: WARNING: RISK FOR ANAPHYLACTIC-TYPE REACTIONS Anaphylactic-type reactions, including fatalities, have followed the parenteral administration of iron dextran injection. This calculator will help pinpoint potential causes of anemia based on Avoid or Use Alternate Drug. Mean Corpuscular Hemoglobin Concentration (MCHC) Calculator, Red Blood Cell (RBC) Indices Calculator, Iron Deficiency In Pregnancy Calculator. 300-500 mg Iron Sucrose in NS 250 mL administered over three (3) hours; may repeat as needed in 3-7 days to reach 1 gm. Applies only to oral form of both agents. Interaction only with oral iron administration. If you notice other effects not listed above, contact your doctor or pharmacist.In the US -Call your doctor for medical advice about side effects. A maximum dose of 1000 mg iron can be delivered intravenously over 15 minutes, which may make it a suitable treatment for iron-deficiency anaemia outside of the hospital setting. calcium carbonate decreases levels of iron sucrose by inhibition of GI absorption. PDF Protocol for the use of Intravenous Iron Sucrose (Venofer Most Monitor Closely (1)omeprazole will decrease the level or effect of iron sucrose by increasing gastric pH. Applies only to oral form of both agents. Monitor for signs and symptoms of hypotension following each Feraheme infusion. Administer Venofer only intravenously by slow injection or by infusion. Applies only to oral form of both agents. PDF Iron dosing and administration in adults backgrounder A: Generally acceptable. Adult Patients with Non-Dialysis Dependent-Chronic Kidney Disease (NDD-CKD): Administer Venofer 200 mg undiluted as a slow intravenous injection over 2 to 5 minutes or as an infusion of 200 mg in a maximum of 100 mL of 0.9% NaCl x 15 minutes. Minor/Significance Unknown. Monitor Closely (1)sodium citrate/citric acid will decrease the level or effect of iron sucrose by increasing gastric pH. Total dose iron infusion: safety and efficacy in predialysis patients. Applies only to oral form of both agents. iron sucrose decreases levels of manganese by inhibition of GI absorption. Feraheme, when added to intravenous infusion bags containing either 0.9% Sodium Chloride Injection, USP (normal saline), or 5% Dextrose Injection, USP, at concentrations of 2-8 mg elemental iron per mL, should be used immediately but may be stored at controlled room temperature (25C 2C) for up to 4 hours or refrigerated (2-8 C) for up to 48 hours. FERAHEME was non-inferior to Venofer (iron sucrose) in mean Hgb rise from baseline 2,5. Elemental iron product this is a choice between three iron supplement products: Iron dextran 50 mg/mL, Iron sucrose 20 mg/mL and Ferric gluconate 12.5 mg/mL. Ferrlecit has been administered at sequential dialysis sessions by infusion or by slow intravenous injection during the dialysis session itself. Avoid or Use Alternate Drug. IDA symptoms vary, may not be specific and include tiredness, weakness, shortness of breath. Parenteral iron product is iron sucrose (C = 20 mg elemental iron/mL). Applies only to oral form of both agents. Sodium ferric gluconate (Ferrlecit) 62.5 mg . Avoid or Use Alternate Drug. INDICATIONS AND USAGE: Intravenous or intramuscular injections of INFeD are indicated for treatment of patients with documented iron deficiency in whom oral administration is unsatisfactory or impossible. ibuprofen/famotidine will decrease the level or effect of iron sucrose by increasing gastric pH. Baloxavir may bind to polyvalent cations resulting in decreased absorption. There is limited experience with administration of an infusion of 500 mg of Venofer, diluted in a maximum of 250 mL of 0.9% NaCl, over a period of 3.5 to 4 hours on Day 1 and Day 14 [see How Supplied/Storage and Handling (16.2). 1. Alternatively the total dose may be calculated: Dose (mL) = 0.0442 (Desired Hb - Observed Hb) x LBW + (0.26 x LBW) Based on: Desired Hb = the target Hb in g/dl. lansoprazole will decrease the level or effect of iron sucrose by increasing gastric pH. Use Caution/Monitor. For iron maintenance treatment, administer Venofer, (2 years of age or older) with NDD-CKD or PDD-CKD who are on erythropoietin therapy for iron maintenance treatment. Monitor Closely (1)dexlansoprazole will decrease the level or effect of iron sucrose by increasing gastric pH. The original formula employs the weight in kg but users can input it in lbs and it gets transformed. DOSAGE AND ADMINISTRATION: Venofer must only be administered intravenously either by slow injection or by infusion. For iron maintenance treatment: Administer Venofer at a dose of 0.5 mg/kg, not to exceed 100 mg per dose, every four weeks for 12 weeks given undiluted by slow intravenous injection over 5 minutes or diluted in 0.9% NaCl at a concentration of 1 to 2 mg/mL and administered over 5 to 60 minutes. Iron supplements, whether administered orally, intramuscular or intravenous, are used to replenish body stores and correct anemia. Medscape prescription drug monographs are based on FDA-approved labeling information, unless otherwise noted, combined with additional data derived from primary medical literature. Modify Therapy/Monitor Closely. Intravenous iron sucrose for children with iron deficiency anemia: a Monitor Closely (1)deferasirox decreases levels of iron sucrose by inhibition of GI absorption. Iron supplements, regardless of their way of administration, are used to replete body stores and to correct anemia. Applies only to oral form of both agents. Applies only to oral form of both agents. ONE DOSE. Applies only to oral form of both agents. Pediatric Patients (2 Years of Age and Older). Slowing the infusion rate may alleviate symptoms. Applies to didanosine chewable tablets and powder for oral solution; administer 2 hr before or several hours after didanosine oral solution or chewable tablet administration. Use Caution/Monitor. 1974 Jun;31(6):592-5. Use Caution/Monitor. Monitor Closely (1)iron sucrose decreases levels of penicillamine by inhibition of GI absorption. iron sucrose decreases levels of eltrombopag by inhibition of GI absorption. Most studies have used IV iron sucrose (maximum dose of 200 mg per setting) or ferric carboxymaltose (maximum dose of 1000 mg per week). Applies only to oral form of both agents. All Rights Reserved. Steps on how to print your input & results: 1. Copyright 2014 - 2023 The Calculator .CO |All Rights Reserved|Terms and Conditions of Use, Intravenous iron-dextran: therapeutic and experimental possibilities, Intravenous Iron Therapy in Patients with Iron Deficiency Anemia: Dosing Considerations, Treatment of iron deficiency anemia associated with gastrointestinal tract diseases, Diagnosis and management of iron deficiency anaemia: a clinical update. Minor (2)calcium gluconate decreases levels of iron sucrose by inhibition of GI absorption. Minor (2)calcium chloride decreases levels of iron sucrose by inhibition of GI absorption. iron sucrose decreases levels of moxifloxacin by inhibition of GI absorption. Applies only to oral form of both agents. 2010niferex-hytinic-polysaccharide-iron-342160Drugs, You are being redirected to and formulary information changes. If hypersensitivity reactions or signs of intolerance occur during administration, stop Venofer immediately. Use Caution/Monitor. Either increases effects of the other by pharmacodynamic synergism. sodium sulfate/?magnesium sulfate/potassium chloride decreases levels of iron sucrose by inhibition of GI absorption. Use Caution/Monitor. Dosage: For patients weighing 50 kg (110 lb) or more: Give Injectafer in two doses separated by at least 7 days. Calculation of Iron Deficit - Perinatology.com Anemia; 2015: 763576. Initial symptoms may include hypotension, syncope, unresponsiveness, cardiac/cardiorespiratory arrest. Applies only to oral form of both agents. 2010; 193(9):525-32. Minor/Significance Unknown. Drug Dosing in Obesity Reference Table - ClinCalc.com By entering this website, you acknowledge that you are a licensed healthcare professional practicing in the United States. Use Caution/Monitor. Serious - Use Alternative (1)iron sucrose decreases levels of eltrombopag by inhibition of GI absorption. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Serious - Use Alternative (1)iron sucrose decreases levels of ofloxacin by inhibition of GI absorption. Monitor Closely (1)calcium carbonate will decrease the level or effect of iron sucrose by increasing gastric pH. Venofer (iron sucrose) dose, indications, adverse effects - PDR