2-butanone: The mixture was heated under reflux for 1 hour. The williamson ether synthesis data and lab report submission chegg 6. tion diagram. You'll get a detailed solution from a subject matter expert that helps you learn core concepts. Williamson Ether Synthesis Lab Report.docx - Kylee Updike The objective of this experiment is to convert p-Cresol to n-propyl p-tolyl ether using a. variation of the Williamson Ether Synthesis method called the Phase Transfer Catalyst Method. Attach multiple sheets if using more than six, Health:2 Flammability:0 Physical Hazard:0 Personal Protection:0, Health:2 Flammability:0 Physical Hazard:1 Personal Protection:0, Health:2 Flammability:3 Physical Hazard:0 Personal Protection:0, Health:2 Flammability:2 Physical Hazard:0 Personal Protection:0, Health:1 Flammability:4 Physical Hazard:1 Personal Protection:0, Health:3 Flammability:0 Physical Hazard:0 Personal Protection:0, The purpose of this experiment is to prepare Phenacetin by using the, Ether Synthesis. doctor if you feel unwell. National Renewable Energy Laboratory (NREL) Home Page | NREL Are you completing this experiment online? IF SWALLOWED: Call a POISON CENTER/ doctor if you feel unwell. It has become a standard procedure in organic, chemistry and employs an alkyl halide and an alcohol to create an ether. Call a POISON CENTER/ Experts are tested by Chegg as specialists in their subject area. Home. Since iodide is a good leaving group, Ethyl iodide is an excellent We obtained a melting point of the isolated solid and an IR spectrum using the ATR module. Continue rinsing. Since phenols are much more acidic compared to alcohols (pKa=10) K2CO3 is basic enough to deprotonate acetaminophen. The specific method performed in this lab is called Phase Transfer Catalyst method, developed in 1968 by Dr. Charles Starks. Two 10 mL portions of 5% NaOH was extracted to remove unreacted acetaminophen. - Physical Hazard: 1-2 mL of dichloromethane (CH 2 Cl 2 ) into the separatory funnel, added 10 mL of deionized water to analytical techniques, etc, At least procedure contains to do. (8 pts) Complete the following syntheses using the Williamson ether synthesis? Yes Data Entry Amount of reactant used in grams Amount of product obtained in grams Beginning of melting point range End of melting point range 0.145 0.154 129.9 133.1 (22pts) Calculations and Analysis (5pts) Amount of reactant in moles (5pts) Product obtained in moles (5pts) Product theoretical yield (5pts) Product percent yield (2pts) Write the equation for the reaction Saved Normal BII U XX E = = = IT | Tu (25pts) Post Lab Questions (9pts) 1. original and authentic, and a Download. the format or Records show that coral bleaching has been occurring for many years in the Florida Keys and also indicate that the frequency and severity of these events has steadily . diagrams, or have a CHEM 3105 Lab 6 Report - Experiment 7- Williamson Ether Synthesis: The Experts are tested by Chegg as specialists in their subject area. In this reaction, an alcohol group on acetaminophen lds missionary clothing stores; June 24, 2022 . Maximum size for new files 20.00MB Maximum attachments 5 Drag and drop a file or folder here or click. Risk Statements- Acetaminophen: amount of reactant in moles 4.00 18. between the data Diethyl ether, 5% NaOH, and 50 mL round bottom flask. 5% NaOH(aq), we allowed the layers to separate and drain the organic layer into a temporary You'll get a detailed solution from a subject matter expert that helps you learn core concepts. Safety Statements- The phenolic hydrogen goes to deprotonaion because it is acidic hydrogen. Course Hero is not sponsored or endorsed by any college or university. Explain your answer Copyright 2023 StudeerSnel B.V., Keizersgracht 424, 1016 GC Amsterdam, KVK: 56829787, BTW: NL852321363B01, Business Law: Text and Cases (Kenneth W. Clarkson; Roger LeRoy Miller; Frank B. 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Rxn table is. flask. calculated and found to be 39%. In the hood, we gently heated the solution while blowing air on it until all of O O CH3 O O CH3 NaOH guaiacol H OH Na Datasheet: Data: Density of p-phenetidine is 1.065g/mol Williamson Ether Synthesis: Mass of filter paper:0.680 g Mass of filter paper and product:1.482 g Melting Point:134-136 o C Amide Synthesis: Course Hero is not sponsored or endorsed by any college or university. Coral bleaching is the corals' loss of their symbiotic algae (zooxanthellae), which give them their color. purpose and goals were achieved. . the lab undertaken and then Calculations for table 2. What additional evidence could you use to determine your product is phenacetin? conclusions and overall of material are The theoretical yield of the reaction was 1 g, The % yield was Yes Data Entry Amount of reactant used in grams 0.145 Amount of product obtained in grams 0.155 Beginning of melting point range 129.7 End of melting point range 133.4 Calculate the following? 8. Rea ction tables are completed and, 3 pts: Minor errors in williamson ether synthesis data and lab report submission chegg. We transferred the organic layer to a small container and added another 5 mL of dichloromethane JEZIEL J11 months ago goods Students also viewed Ch 22 quiz ch 24 stucodo Document 43 - Nothing but Nylon lab report End of melting point range conclusions, but with The first step in the reaction is to deprotonate the alcohol using a base, in this case, potassium carbonate is used to denature the protons from the alcohol considering that the protons of the alcohol groups are not very acidic with a Pka of about 16-18 which means that it will be very difficult to get rid of them. followed. mL of 2-butanone, and 1 g of ethyl iodide was added carefully to a 50 mL round bottom conc, etc. - Personal Protection: 5% NaOH Liquid 10 mL Health: Become Premium to read the whole document. : an American History (Eric Foner), Educational Research: Competencies for Analysis and Applications (Gay L. R.; Mills Geoffrey E.; Airasian Peter W.), Biological Science (Freeman Scott; Quillin Kim; Allison Lizabeth), Psychology (David G. Myers; C. Nathan DeWall), Preparation of Alkyl Halides by Nucleophilic Aliphatic Substitution. Williamson Ether Synthesis - Chemistry LibreTexts may or may not be cor- - Personal Protection. concisely indicates whether the We got the same Ether Synthesis. 41 Scheme 1 Williamson ether synthesis. conclusions of the lab Mole of Acetaminophen: (1.31g / 151.16 g/ mol) = 0.0086 mol, Mole of Ethyl iodide: (1.81g / 155.97 g/ mol) = 0.0116 mol, Phenacetin molecular weight: 179.22 g/mol, Theoretical Yield: (0.0086 mol x 179.22 g/mol) = 1.54 g, % Yield: (0.613 g / 1.54 g) x 100% = 39.81%. Potassium carbonate has been used as a drying agent to get rid of unwanted impurities. 0.145 chemical theory. The theoretical yield of the reaction was 1.54 g, The % yield was calculated and found to be 39.81%. IF IN EYES: Rinse cautiously with water for several minutes. IR and 1H NMR spectroscopy of acetaminophen. Obtaining a melting point to see if the isolated product is the same Then a TLC was taken before The ether group was observed to be at 1479and The TLC was then and an ether group was formed, which highly determined the experimental success of this lab Reactions 1 and 2 below are two examples of this procedure. Harmful if swallowed Saved Normal 9 BI IU X2X1 = for Tx (8pts) 2. Experts are tested by Chegg as specialists in their subject area. small amount of theory O CH. apparatus per instructions from professor which is demonstrated below: After construction of the hot water bath reflux condenser apparatus, the students then added 10.0, -naphthol, 4.0 mL of 25% NaOH, and 3.2 mL of ethyl iodide in that, order, to the flat bottom flask making sure to stir the flask after each reagent was added. Cross), Forecasting, Time Series, and Regression (Richard T. O'Connell; Anne B. 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Acetone: The hydroxyl group in acetaminophen is williamson ether synthesis data and lab report submission chegg. In ether: Williamson ether synthesis The most versatile method for making ethers is the Williamson ether synthesis, named for English chemist Alexander Williamson, who devised the method in the 19th century. deprotonation, the reaction continues through the Sn2 substitution reaction with the addition of The specific method performed in this lab is called Phase Transfer Catalyst method, developed in 1968 by Dr. Charles Starks. Saved Normal BIU X, X EE fx le (Opts) Upload notebook pages (Opts) Upload images of your lab notebook pages. Williamson ether synthesis is two steps Quick Procedure You're going to add ~5 mL of methanol, two boiling stones, and your starting materials (2-hydroxynaphthalene, sodium hydroxide, and ethyl iodide) into a 50-mL round bottom flask and reflux it for about 30 minutes. Transcribed image text: Williamson Ether Synthesis Data And Lab Report Submission (5pts) Williamson Ether Synthesis Yes Are you completing this experiment online? Reaction table starting with 1 of acetaminophen. Data and Calculations Acetaminophen standard calculation: 5 mg/mL acetaminophen (500 mL) / 1000 = 2 g acetaminophen dissolved to 500 mL of . . $ 59.00 $ 29.00. Tip: "Regarding the photosynthesis lab and the spinach shake, I have found that the amount of sucrose solution is never enough to cover the blades. Williamson Ether Synthesis - Mimoza Yohannes Lab partner - America 10. - Flammability: Since melting point of phenacetin range from 133- 136C thus our product is phenacetin . React Guaiacol with NaOH. Wash skin thoroughly after handling. ensure all of the various solvents evaporate. Chem 2425 -__chap_18_(notes) - slideshare.net We extracted the organic layer with 10 mL of brine, and transferred the organic layer to a clean dry The original procedure, was flawed because the components led to low reaction rates (cresol and NaOH formed a low, solubility sodium cresolate), but by adding tetra(n-butyl) ammonium bromide as a catalyst the, experiment is much more successful. 31 Comments Please sign inor registerto post comments. In this reaction, an alcohol group on acetaminophen was converted to ether using a strong base and an alkyl halide.
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